COVID-19 disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a global pandemic for almost 2 years now. Developing vaccines and mass roll out became a priority to reduce the severity of COVID-19 impact globally. To date, Botswana Medicines regulatory authority (BoMRA) has listed several COVID-19 vaccines for emergency use. BoMRA is mandated to monitor safety of COVID-19 vaccines used in Botswana. The authority monitors the safety of these vaccines through analysis of reported Adverse Events Following Immunisation (AEFIs), analysis of AEFIs on global database, data mining from medical literature and from the experience of other national regulatory authorities in the region and around the globe.